The Effect of Acute Hyperglycemia on Flow Velocity In the

been demonstrated following adrenalectomy in rats. The present study support's these results. In both cases (rabbit-ciliary process epithelium and rat myocardium), corticosteroids lowered the ka for isoproterenol stimulation of the cyclase and were without effect on enzyme activity under basal or maximally stimulating conditions. Corticosteroid-induced potentiation of ciliary process-j8-adreriergic response is a plausible mechanism by which acute pharmacologic doses of glucocorticoids elevate IOP and increase aqueous flow. Further investigation of such a mechanism may clarify the relationship between chronically elevated plasma cortisol levels and elevated IOP as reported by Schwartz and Levene.